Sjögren's disease & overlap diseases
Clinical and histological features of patients with primary Sjögren's syndrome and autoimmune thyroiditis: a national multicentre cross-sectional study
Authors' conclusion
We confirm a high association between pSS and AT and describe the presence of a different phenotype characterized by a higher rate of celiac disease and fibromyalgia.
Study context
- Population
- National cohort of patients with Primary Sjögren's syndrome (pSS)
- Participants
- 2,546 participants
- Exposure
- pSS with AT vs pSS without AT
- Outcome
- Prevalence of autoimmune thyroiditis in pSS
Methodological detailsmulticentre, national cohort
- Multicentre
- National cohort
Main finding
As reported in the abstract
Prevalence of concomitant pSS and AT
Concomitant pSS and AT
19.6%
Observational data: associations, not effects.
Further findings
Clinical phenotype, pSS with vs without AT
- pSS with AT: lower prevalence of lymphoma, male sex and DMARD use; higher prevalence of fibromyalgia, coeliac disease and hypergammaglobulinaemia
- Multivariable analysis confirmed higher prevalence of fibromyalgia and coeliac disease and lower DMARD use
Minor salivary gland histology (subgroup, n=232)
- Significantly higher focus score and number of foci in pSS without AT (n=169) vs pSS with AT (n=54)
Original publication
Clinical and histological features of patients with primary Sjögren's syndrome and autoimmune thyroiditis: a national multicentre cross-sectional study. Clin Exp Rheumatol. Published 23 December 2023. doi:10.
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