Long‐Term Outcomes of Children Born to Anti‐Ro Antibody–Positive Mothers With and Without Rheumatic Disease
Authors' conclusion
In a large multiethnic cohort of infants born to anti-Ro antibody-positive mothers, there was no significant difference in the prevalence of allergic, neurodevelopmental, or autoimmune diseases between children with and without NLE or between those born to anti-Ro antibody-positive mothers and a population-based non-NLE cohort.
Study context
- Population
- Children aged ≥1 year born to anti-Ro antibody-positive mothers, neonatal lupus erythematosus (NLE) clinic at The Hospital for Sick Childrenmedian age 6 years
- Participants
- 321 children
- Exposure
- Children with vs without NLE; mothers with vs without rheumatic disease; NLE cohort vs population-based CHILD cohort
- NLEn = 162
- Outcome
- Prevalence of allergic, neurodevelopmental and autoimmune diagnoses
Methodological detailssingle-centre (NLE clinic, The Hospital for Sick Children), health status questionnaire, comparison with population-based CHILD Cohort Study, logistic regression, P < 0.006 considered significant
- Single-centre (NLE clinic, The Hospital for Sick Children)
- Health status questionnaire
- Comparison with population-based CHILD Cohort Study
- Logistic regression
- P < 0.006 considered significant
Main finding
As reported in the abstract
Any disease prevalence
- No significant difference between children born to mothers with and without a rheumatic disease (P = 0.11)
- NLE vs Without NLE: P = 0.57
Observational data: associations, not effects.
Further findings
| Outcome | NLE | CHILD | P value |
|---|---|---|---|
| Allergic disease prevalence, NLE vs CHILD cohorts | 30% | 22% | P = 0.25 |
| Neurodevelopmental conditions prevalence, NLE vs CHILD cohorts | 5% | 2% | P = 0.45 |
| Autoimmune disease prevalence, NLE vs CHILD cohorts | 4% | 2% | P = 0.68 |
Original publication
Long‐Term Outcomes of Children Born to Anti‐Ro Antibody–Positive Mothers With and Without Rheumatic Disease. Arthritis Care Res (Hoboken). Published 15 March 2025. doi:10.
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