Long noncoding RNAs (CTC-471J1.2, NeST) as epigenetic risk factors of active juvenile lupus nephritis: a case-control study
Authors' conclusion
The expression level of circulatory lncRNAs-CTC-471J1.2 and NeST can be used as sensitive and specific biomarkers for active LN.
Study context
- Population
- Children with juvenile lupus nephritis (LN) attending Mansoura University Children's Hospital (MUCH)
- Comparison
- Active LN vs inactive LN vs controls
- Outcome
- Expression of lncRNAs CTC-471J1.2 and NeST (quantitative real-time PCR) and correlation with disease activity
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Circulating lncRNA expression
- CTC-471J1.2 significantly down-regulated in active LN vs inactive cases or controls
- NeST significantly up-regulated in active LN
- Significant correlation between CTC-471J1.2 expression and LN activity parameters
Observational data: associations, not effects.
Further findings
Diagnostic performance for active LN
- Both lncRNAs showed reasonable sensitivity and specificity in differentiating active LN
Regression analysis
- CTC-471J1.2 and NeST were independent predictors of active nephritis
Original publication
Long noncoding RNAs (CTC-471J1.2, NeST) as epigenetic risk factors of active juvenile lupus nephritis: a case-control study. Pediatr Rheumatol Online J. Published 27 April 2024. doi:10.
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