Blood brain barrier permeability and astrocyte-derived extracellular vesicles in children with juvenile idiopathic arthritis: a cross-sectional study
Authors' conclusion
The elevated levels of astrocyte-derived EVs and the presence of S100B in children with JIA provide evidence of BBB disruption and CNS involvement, particularly in those with higher disease activity.
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) and age- and gender-matched healthy controls
- Participants
- 90 vs 10
- Exposure
- Children with JIA vs healthy controls
- JIAn = 90
- Healthy controlsn = 10reference
- Outcome
- Plasma astrocyte-derived EVs (AQP-4, glial fibrillary acidic protein (GFAP); flow cytometry) and S100B protein (ELISA)
Methodological detailscontrols matched by age and gender
- Controls matched by age and gender
Main finding
As reported in the abstract
Plasma astrocyte-derived EVs
- Significantly higher concentration of astrocyte-derived extracellular vesicles (EVs) in children with JIA vs healthy controls
- S100B detectable exclusively in the JIA group
Observational data: associations, not effects.
Further findings
Astrocyte-derived EVs by disease activity (Juvenile Arthritis Disease Activity Score (JADAS27))
- Notably higher levels of these EVs with JADAS27 scores of 1 or higher
Original publication
Blood brain barrier permeability and astrocyte-derived extracellular vesicles in children with juvenile idiopathic arthritis: a cross-sectional study. Pediatr Rheumatol Online J. Published 26 April 2024. doi:10.
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