Differentially Expressed Inflammation-Regulating MicroRNAs in Oligoarticular Juvenile Idiopathic Arthritis
Authors' conclusion
The expression of multiple microRNAs is dysregulated in JIA both locally and systemically, which may inhibit the TGF-β pathway.
Study context
- Population
- Patients with juvenile idiopathic arthritis (JIA) (oligoarticular) and healthy controls
- Comparison
- JIA plasma, synovial fluid (SF) and leukocytes vs HC blood and JIA blood
- Outcome
- MicroRNA expression in SF, plasma and leukocytes
Methodological detailsdroplet digital PCR array, validation in individual patient samples, pathway analysis
- Droplet digital PCR array
- Validation in individual patient samples
- Pathway analysis
Main finding
As reported in the abstract
MicroRNA expression
- MiR-15a-5p and miR-409-3p higher in JIA plasma than in HC plasma
- JIA SF: elevated miR-21-5p, miR-27a-3p, miR-146b-5p, miR-155-5p and miR-423-5p, decreased miR-192-5p and miR-451a vs JIA plasma
- Only miR-155-5p represented substantially in extracellular vesicles
- SF leukocytes: higher miR-21-5p, miR-27a-3p, miR-146b-5p and miR-155-5p, lower miR-409-3p and miR-451a vs blood
- No differences between JIA and HC blood leukocytes
- Differentially expressed microRNAs predicted in silico to target the transforming growth factor (TGF)-β pathway
Original publication
Differentially Expressed Inflammation-Regulating MicroRNAs in Oligoarticular Juvenile Idiopathic Arthritis. J Rheumatol. Published 15 July 2022. doi:10.
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