Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review
Authors' conclusion
Both linear lncRNAs and circRNAs play critical roles in unraveling the mechanisms underlying KD, contributing to biomarker identification and potential therapeutic advances.
Study context
- Population
- Individuals diagnosed with Kawasaki disease
- Participants
- 1,894 individuals9 studies
- Outcome
- lncRNAs and circRNAs associated with KD
Methodological detailsfour databases (PubMed, Embase, Scopus, Web of Science) up to June 19, 2023, risk of bias assessed with Newcastle-Ottawa Scale
- Four databases (PubMed, Embase, Scopus, Web of Science) up to June 19, 2023
- Risk of bias assessed with Newcastle-Ottawa Scale
Pooled result
As reported in the abstract
Seven long non-coding RNAs (lncRNAs) associated with Kawasaki disease (KD): Slco4a1, SOCS2-AS1, SRA, HCG22, MHRT, XLOC_006277, HSD11B1-AS1, including polymorphisms lncRNA rs1814343 C > T and AC008392.1 rs7248320
7
Four circRNAs associated with KD: circRNA-3302, circ7632, circANRIL, hsa_circ_0123996
4
Original publication
Role of long non-coding RNAs and circular RNAs in kawasaki disease: a systematic review. Pediatr Rheumatol Online J. Published 13 June 2025. doi:10.
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