Lupus & antiphospholipid syndrome
Juvenile neuropsychiatric systemic lupus erythematosus: A specific clinical phenotype and proposal of a probability score
Authors' conclusion
For j-NPSLE patients with predominant psychiatric features, a multidisciplinary collaboration, including psychiatrists, is essential for the diagnosis, management and follow-up.
Study context
- Population
- Patients with juvenile SLE (juvenile systemic lupus erythematosus (j-SLE)), single centre
- Participants
- 39 patients
- Exposure
- j-NPSLE vs j-SLE without neuropsychiatric (NP) involvement
- Outcome
- Prevalence of j-NPSLE and its clinical features
Methodological detailsmonocentric, 4-year, multivariable logistic regression
- Monocentric
- 4-year
- Multivariable logistic regression
Main finding
As reported in the abstract
| Group | Value | Diagnosis at onset of j-SLE | Kidney involvement | Chilblains | Cognitive symptoms | Hallucinations | Depressed mood | Acute confused state | Catatonia | Headache | Magnetic resonance imaging (MRI) nonspecific T2/FLAIR white matter hyperintensities | MRI cerebral atrophy |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| j-NPSLE | 44% | 59% | 76% | 65% | 82% | 76% | 35% | 18% | 12% | 53% | 65% | 88% |
j-NPSLE
Value44%
Diagnosis at onset of j-SLE59%
Kidney involvement76%
Chilblains65%
Cognitive symptoms82%
Hallucinations76%
Depressed mood35%
Acute confused state18%
Catatonia12%
Headache53%
Magnetic resonance imaging (MRI) nonspecific T2/FLAIR white matter hyperintensities65%
MRI cerebral atrophy88%
Observational data: associations, not effects.
Further findings
j-NPSLE probability score (hallucinations, memory, sleep, renal involvement)
- Sensitivity
- 0.95
- Specificity
- 0.85
- Cerebrospinal fluid (CSF) neopterin assessment increases the score sensitivity and specificity
Original publication
Juvenile neuropsychiatric systemic lupus erythematosus: A specific clinical phenotype and proposal of a probability score. Lupus. Published 5 February 2024. doi:10.
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