Lupus & antiphospholipid syndrome
Association of disease activity with depression and anxiety in systemic lupus erythematosus: a comparison of SLEDAI-2K and Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS)
Authors' conclusion
The SLE-DAS scoring system demonstrated a comparable ability to assess disease activity in SLE compared with SLEDAI-2K. Though neither scoring system showed significant associations with depression and anxiety, the presence of mucosal ulcer/serositis markedly heightened the risk of both among SLE patients.
Study context
- Population
- Chinese patients with SLE
- Participants
- 85 patients
- Outcome
- Association of disease activity (SLE-DAS and SLEDAI-2K) with depression (Patient Health Questionnaire-9) and anxiety (Generalized Anxiety Disorder Scale-7)
Methodological detailsmultivariate logistic regression
- Multivariate logistic regression
Main finding
As reported in the abstract
Mucosal ulcer/serositis and depression, OR
4.472
95% CI 1.035–19.328P = 0.045
Mucosal ulcer/serositis and anxiety, OR
3.978
95% CI 1.051–15.049P = 0.042
Observational data: associations, not effects.
Further findings
Correlation between SLEDAI-2K and SLE-DAS scores
- Overall population, Spearman's r
- 0.764 (95% CI 0.655-0.842; P < 0.001)
- Moderate-to-high disease activity, Spearman's r
- 0.792 (95% CI 0.616-0.892; P < 0.0001)
- Mild disease activity or remission, Spearman's r
- 0.450 (95%CI 0.188-0.652; P = 0.001)
Original publication
Association of disease activity with depression and anxiety in systemic lupus erythematosus: a comparison of SLEDAI-2K and SLE-DAS. Rheumatology (Oxford). Published 1 February 2024. doi:10.
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