Lupus & antiphospholipid syndrome
Multidisciplinary re-evaluation of neuropsychiatric events to confirm the neuropsychiatric lupus diagnosis at an Indonesian tertiary hospital
Authors' conclusion
Multidisciplinary re-evaluation can be used as a method to confirm the diagnosis of NPSLE. There is a tendency for overdiagnosis of NPSLE when clinicians are faced with NP events in patients with SLE.
Study context
- Population
- Patients >18 years with SLE and neuropsychiatric (NP) manifestations, Indonesian tertiary hospital94 subjects
- Participants
- 132 NP events
- Exposure
- Initial vs multidisciplinary re-evaluated diagnosis of NP events
- Neuropsychiatric SLE (NPSLE)n = 69
- Non-NPSLEn = 63reference
- Outcome
- Final diagnosis of NPSLE or non-NPSLE after multidisciplinary re-evaluation
Methodological detailssingle-centre, multidisciplinary re-evaluation
- Single-centre
- Multidisciplinary re-evaluation
Main finding
As reported in the abstract
NP events confirmed/declared NPSLE after re-evaluation
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Disease activity and serology, NPSLE vs non-NPSLENPSLE vs Non-NPSLE | P < 0.001 |
| Disease activity and serology, NPSLE vs non-NPSLENPSLE vs Non-NPSLE | P = 0.02 |
| Disease activity and serology, NPSLE vs non-NPSLENPSLE vs Non-NPSLE | P = 0.03 |
| Disease activity and serology, NPSLE vs non-NPSLENPSLE vs Non-NPSLE | P < 0.001 |
| Disease activity and serology, NPSLE vs non-NPSLENPSLE vs Non-NPSLE | P = 0.018 |
| Disease activity and serology, NPSLE vs non-NPSLENPSLE vs Non-NPSLE | P = 0.001 |
Demographic characteristics, NPSLE vs non-NPSLE
- No significant differences
Proportion of NP events
- Almost the same in both groups except cerebrovascular disease, more common in NPSLE
Original publication
Multidisciplinary re-evaluation of neuropsychiatric events to confirm the neuropsychiatric lupus diagnosis at an Indonesian tertiary hospital. Lupus Sci Med. Published 8 June 2024. doi:10.
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