Lupus & antiphospholipid syndrome
Factors affecting different COVID-19 outcomes in patients with systemic lupus erythematosus during the second pandemic wave of COVID-19 in China
Authors' conclusion
Different COVID-19 outcomes in people with SLE are mostly driven by COVID-19 vaccination, medications, and activity SLE. More importantly, three doses of COVID-19 vaccination may be associated with better outcomes.
Study context
- Population
- People with systemic lupus erythematosus (SLE) and COVID-19 who visited the First Affiliated Hospital of Nanchang University, December 2022–February 2023 (second pandemic wave, China)2 deaths
- Participants
- 301 people
- Outcome
- COVID-19 severity on an ordinal scale: not hospitalized; hospitalized without oxygenation; hospitalized with any ventilation or oxygenation (2 deaths included in the most severe category)
Methodological detailssingle-centre, multivariable ordinal logistic regression
- Single-centre
- Multivariable ordinal logistic regression
Main finding
As reported in the abstract
Factors associated with more severe COVID-19 outcome (multivariable ordinal logistic regression)
Odds ratio (95% CI)P value
High SLE disease activityvs Remission
39.04(3.08–494.44)
P = 0.005Three doses of COVID-19 vaccination
0.19(0.07–0.51)
P = 0.001GC 1-5 mg/day
0.14(0.03–0.73)
P = 0.020GC 6-9 mg/day
0.12(0.02–0.61)
P = 0.010More intensive immunosuppression drugs
0.34(0.12–0.97)
P = 0.044Observational data: associations, not effects.
Further findings
Medications and more severe COVID-19 outcome (age- and sex-adjusted models)
| OR (95% CI) | P value | ||
|---|---|---|---|
| TelitaciceptAge-adjusted and sex-adjusted models | 6.66 (1.35–32.86) | P = 0.020 | |
| RTXAge-adjusted and sex-adjusted models | 7.81 (1.87–32.66) | P = 0.005 | |
| HCQAge-adjusted and sex-adjusted models | 0.47 (0.25–0.88) | P = 0.018 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Factors affecting different COVID-19 outcomes in patients with systemic lupus erythematosus during the second pandemic wave of COVID-19 in China. Lupus. Published 5 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →