J-shaped association of serum uric acid concentrations with all-cause mortality in individuals with osteoarthritis: A prospective cohort study
Authors' conclusion
There is a nonlinear relationship between SUA concentrations and all-cause mortality in the American OA population (J-shaped association). The all-cause mortality thresholds for SUA concentrations in females and males are 5.6mg/dl and 6.2mg/dl, respectively.
Study context
- Population
- Individuals with osteoarthritis (OA) aged 20 to 85 years, National Health and Nutrition Examination Survey; deaths from the National Death Index up to December 31, 2019
- Participants
- 4,671 individuals30,645 person-years
- Exposure
- Serum uric acid (SUA) concentrations above vs below the inflection point
- Femalesn = 2,988
- Malesn = 1,683
- Outcome
- All-cause mortality
Methodological detailsNHANES database, Cox proportional hazards model, two-segment Cox proportional hazards model, multivariate adjustment, interaction test
- NHANES database
- Cox proportional hazards model
- Two-segment Cox proportional hazards model
- Multivariate adjustment
- Interaction test
Main finding
As reported in the abstract
All-cause mortality, SUA above vs below inflection point (5.6mg/dl females, 6.2mg/dl males)
Females
736
events
Males
516
events
Hazard ratio (95% CI)
Females: higher SUAvs Females: SUA below inflection pointrisk increased by 20%
1.2(1.1–1.2)
Males: higher SUAvs Males: SUA below inflection pointrisk increased by 25%
1.2(1.12–1.39)
Observational data: associations, not effects.
Original publication
J-shaped association of serum uric acid concentrations with all-cause mortality in individuals with osteoarthritis: A prospective cohort study. Joint Bone Spine. Published 22 December 2023. doi:10.
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