Is rheumatoid arthritis always preceded by a symptomatic at-risk phase of arthralgia?
Main finding · Sustained DMARD-free remission (SDFR)Result — go to the resultHR for achieving SDFR 0.51 95% CI 0.37–0.68Authors' conclusion
These data suggest the notion that the entire RA population has an identifiable symptomatic risk stage should be refuted.
Study context
- Population
- Consecutively diagnosed patients with rheumatoid arthritis (RA), 2012–2022, presenting directly with clinically apparent arthritis or first with clinically suspect arthralgia (CSA)
- Participants
- 699 participants
- Exposure
- RA preceded by clinically suspect arthralgia (CSA) vs RA presenting directly with clinically apparent arthritis
- Outcome
- Sustained DMARD-free remission (SDFR)
- Follow-up
- Median 5.3 years
Methodological detailsconsecutively diagnosed patients, K-means clustering after partial least squares discriminant analysis
- Consecutively diagnosed patients
- K-means clustering after partial least squares discriminant analysis
Main finding
As reported in the abstract
HR for achieving SDFR
0.51
95% CI 0.37–0.68
Two clusters including almost all patients with a preceding CSA phasevs Two clusters where preceding CSA was infrequent/absent
HR for achieving SDFR 0.51 (95% CI 0.37–0.68)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Is rheumatoid arthritis always preceded by a symptomatic at-risk phase of arthralgia? RMD Open. Published 12 November 2024. doi:10.
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