Patient-reported swelling in arthralgia patients at risk for rheumatoid arthritis: is it of value?
Authors' conclusion
Patient-reported joint swelling in CSA relates to subclinical joint inflammation and is an independent risk factor for RA development, but it is less predictive than the presence of MRI-detected subclinical joint inflammation.
Study context
- Population
- Symptomatic patients with clinically suspect arthralgia (CSA) at risk for rheumatoid arthritis (RA), two CSA cohorts from the Netherlands
- Participants
- 534 patients2 independent cohorts
- Exposure
- Patient-reported swelling vs no patient-reported swelling
- Outcome
- Association of patient-reported swelling with subclinical joint inflammation on imaging (MRI or US) and inflammatory arthritis development
Methodological detailstwo independent, similarly designed cohorts, Netherlands
- Two independent, similarly designed cohorts
- Netherlands
Main finding
As reported in the abstract
Arthritis development
Patient-reported swelling vs No patient-reported swellingHazard ratio (95% CI)
Cohort 1
3.7(2.0–6.9)
Cohort 2
3.4(1.4–8.4)
Observational data: associations, not effects.
Further findings
Association of patient-reported swelling with US-detected synovitis · baseline
- Patient-reported swelling associated with US-detected synovitis, OR
- 2.3 (95% CI: 1.04, 5.3)
Association of patient-reported swelling with subclinical joint inflammation · baseline
- In both cohorts patient-reported swelling was associated with subclinical joint inflammation
Original publication
Patient-reported swelling in arthralgia patients at risk for rheumatoid arthritis: is it of value? Rheumatology (Oxford). Published 11 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →