Vasculitis & polymyalgia rheumatica
Interstitial lung disease in patients with antineutrophil cytoplasmic antibody-associated vasculitis: chest CT patterns and correlation with survival
Authors' conclusion
The typical UIP pattern in AAV-ILD is associated with better survival, particularly in MPO-ANCA patients, suggesting distinct mechanisms for ILD development in MPO vs. PR3-AAV.
Study context
- Population
- Patients with AAV (MPA and GPA) and interstitial lung disease (ILD) confirmed by chest CT, 1997–2021, Mayo AAV Cohortof 1862 in Mayo AAV Cohort
- Participants
- 143 patients
- Exposure
- ILD patterns on chest CT in AAV-ILD
- Typical usual interstitial pneumonia (UIP)n = 44
- Probable UIPn = 13
- Indeterminate for UIPn = 37
- Non-UIPn = 49reference
- Outcome
- Distribution of ILD patterns on chest CT
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | IRR (ratio as printed; typical UIP related with higher survival) |
|---|---|
| Survival in MPO-ANCA patients, typical UIP vs other ILD patterns · 12 months and 10 yearsTypical UIP vs Other ILD patterns · at 12 months | 8.201 |
| Survival in MPO-ANCA patients, typical UIP vs other ILD patterns · 12 months and 10 yearsTypical UIP vs Other ILD patterns · at 10 years | 2.179 |
ILD pattern by antineutrophil cytoplasmic antibody (ANCA) type
%
- Typical UIP pattern most common among MPO-ANCA patients
- 37.4
- Non-UIP pattern most common among PR3-ANCA patients
- 58.3
Characteristics of typical UIP vs non-UIP pattern
%
- Typical UIP: male
- 70.5
- Typical UIP: MPO-ANCA
- 90.0
- Typical UIP: ILD diagnosed before onset of AAV
- 40.9
- Typical UIP: reduced diffusion capacity on pulmonary function tests
Original publication
Interstitial lung disease in patients with antineutrophil cytoplasmic antibody-associated vasculitis: chest CT patterns and correlation with survival. Semin Arthritis Rheum. Published 10 April 2025. doi:10.
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