Integrated multi-omics revealed that dysregulated lipid metabolism played an important role in rheumatoid arthritis (RA) patients with metabolic diseases
Authors' conclusion
The integration of multi-omics data demonstrates that lipid metabolic pathways play a crucial role in RA_MD
Study context
- Population
- Patients with RA, with and without metabolic diseases; gouty arthritis and SLE as disease comparatorsfecal and blood samples
- Participants
- 181 patients
- Comparison
- RA with metabolic diseases vs RA
- Outcome
- Multi-omics features associated with RA_MD vs RA, and multi-omics classifier accuracy for differentiating RA_MD from RA
Methodological detailsintegrated multi-omics, Least Absolute Shrinkage and Selection Operator (LASSO) machine learning
- Integrated multi-omics
- LASSO machine learning
Main finding
As reported in the abstract
Multi-omics classifier differentiating RA_MD from RA, AUC
0.958
Original publication
Integrated multi-omics revealed that dysregulated lipid metabolism played an important role in RA patients with metabolic diseases. Arthritis Res Ther. Published 1 November 2024. doi:10.
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