Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in rheumatoid arthritis development
Authors' conclusion
These findings revealed that glycerophospholipid metabolism plays a crucial role in the development and progression of RA
Study context
- Population
- Rheumatoid arthritis (RA) patients and controls; plasma, stool and PBMC samples113 RA, 75 controls
- Comparison
- Control vs new-onset RA vs chronic RA
- Controln = 75reference
- Outcome
- Multi-omics differences between NORA and CRA (gut microbiota, fungi, plasma metabolites, PBMC gene expression)
Methodological detailsmulti-omics (16S rRNA sequencing, internally transcribed spacer (ITS) sequencing, metabolomics, RNA sequencing), external validation cohort
- Multi-omics (16S rRNA sequencing, ITS sequencing, metabolomics, RNA sequencing)
- External validation cohort
Main finding
As reported in the abstract
Differential metabolites between new-onset RA (NORA) and chronic RA (CRA)
29
Differentially expressed genes between NORA and CRA; Acetylcholinesterase (ACHE) core gene, enriched in glycerophospholipid metabolism pathway
40
Original publication
Comprehensive multi-omics analysis reveals the core role of glycerophospholipid metabolism in rheumatoid arthritis development. Arthritis Res Ther. Published 15 December 2023. doi:10.
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