Integrative multi-omics analysis reveals CXCL10-driven inflammation and TREM2 + macrophage-plasma cell survival niche as hallmarks of late-stage rheumatoid arthritis
Main finding · Diagnostic performance for RA staging (early vs late-stage): three-gene ANN model and CXCL10Result — go to the resultOdds ratio 7.271Authors' conclusion
Late-stage RA appears to be characterized by a CXCL10-driven inflammatory signature and an expanded TREM2 + macrophage-plasma cell survival niche.
Study context
- Population
- Rheumatoid arthritis (RA) patients with synovial tissue samplesbulk RNA-seq n = 19
- Participants
- 51 patients
- Comparison
- Early vs late-stage RA synovium
- Early RAn = 13reference
- Late-stage RAn = 38
- Outcome
- Diagnostic performance for RA staging (early vs late-stage): three-gene ANN model and CXCL10
Methodological detailsmulti-omics, bulk RNA sequencing, single-cell RNA sequencing, machine learning (LASSO, SVM-RFE, random forest), artificial neural network (ANN) model
- Multi-omics
- Bulk RNA sequencing
- Single-cell RNA sequencing
- Machine learning (LASSO, SVM-RFE, random forest)
- ANN model
Main finding
As reported in the abstract
Odds ratio
7.271
P = 0.022
By group
CXCL10
0.767
AUC
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Integrative multi-omics analysis reveals CXCL10-driven inflammation and TREM2 + macrophage-plasma cell survival niche as hallmarks of late-stage rheumatoid arthritis. Arthritis Res Ther. Published 12 February 2026. doi:10.
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