Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features
Authors' conclusion
In this study, we provide a novel and relevant pathological classification of OA synovial inflammation.
Study context
- Population
- Synovial tissue samples from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) collected at the time of total joint replacementlarge cohort
- Exposure
- OA vs RA synovial tissue
- Outcome
- Immune cell infiltration of the synovium (pathotypes)
Methodological detailshistological approaches with semi-quantitative scoring and quantitative digital image analyses, comparative
- Histological approaches with semi-quantitative scoring and quantitative digital image analyses
- Comparative
Main finding
As reported in the abstract
Synovial pathotypes
- OA synovium can be categorised also into three pathotypes, with disease- and stage-specific features
- Pathotypes specifically reflect distinct levels of peripheral inflammation
Observational data: associations, not effects.
Original publication
Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features. Osteoarthritis Cartilage. Published 19 November 2023. doi:10.
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