Osteoarthritis year in review 2023: genetics, genomics, and epigenetics
Authors' conclusion
These advances improve our understanding of the disease's complexity and guide us toward functional assessments of genetic/epigenetic outcomes and toward their translational and clinical applications.
Study context
- Population
- Original research articles on OA genetics, genomics and epigeneticsof 2178 articles identified
- Participants
- 67 articles
Methodological detailssystematic literature search of PubMed (March 17, 2023), original research articles in English published between the OARSI congresses of 2022 and 2023
- Systematic literature search of PubMed (March 17, 2023)
- Original research articles in English published between the OARSI congresses of 2022 and 2023
Main finding
As reported in the abstract
- Current trends in OA genetics: meta-analyses of various cohorts exploring the impact of gene variants on OA-related outcomes, such as pain
- Early developmental changes within the joint influence OA through genetic variations
- Researchers prioritise testing mechanisms and functions of miRNAs, circRNAs and lncRNAs
- Potential drug targets began to emerge; independent validation studies are lacking
- Single cell RNA sequencing revealed unique immune cell populations in the knee; no study reported single nucleus RNA sequencing
Original publication
Osteoarthritis year in review 2023: genetics, genomics, and epigenetics. Osteoarthritis Cartilage. Published 17 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →