Rheumatoid arthritis

Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: National Health and Nutrition Examination Survey (NHANES) 1999-2020 study

Clin Exp RheumatolPublished Cross-sectional study

Authors' conclusion

The results suggest a negative correlation between the ingestion of n-3 and n-6 fatty acids and the risk of rheumatoid arthritis in US adults.

Study context

Population
US adults, NHANES 1999–2020; Rheumatoid arthritis (RA) identified by questionnaire
Participants
50,352 adults
Exposure
Higher vs lowest category of dietary n-3 and n-6 fatty acid intake
Outcome
RA
Methodological detailsNHANES 1999–2020, logistic regression and spline analyses, 24-hour dietary recall, weight-adjusted
  • NHANES 1999–2020
  • Logistic regression and spline analyses
  • 24-hour dietary recall, weight-adjusted

Main finding

As reported in the abstract

RA (adjusted Model 2)
Highest category vs Lowest categoryOdds ratio (95% CI)
n-3 fatty acid intake
0.72(0.60–0.86)
n-6 fatty acid intake
0.76(0.62–0.92)

Observational data: associations, not effects.

Original publication

Exploring the link between dietary omega-3 and omega-6 fatty acid intake and rheumatoid arthritis risk: NHANES 1999-2020 study. Clin Exp Rheumatol. Published 14 December 2023. doi:10.55563/clinexprheumatol/91tmfb

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