Associations between dietary mineral intake and rheumatoid arthritis: evidence from UK Biobank and NHANES
Authors' conclusion
This study supported that dietary mineral intakes were inversely associated with RA, particularly dietary iron, magnesium, phosphorus and copper.
Study context
- Population
- Adults aged 40–70 years without prior RA diagnosis, UK Biobank (April 2009 to December 2019); validation in NHANESmedian follow-up 8.07 years
- Participants
- 123,940 adults
- Exposure
- Higher vs lower dietary mineral intakes
- Outcome
- Incident RA
Methodological detailsCox proportional hazard models, validation in NHANES
- Cox proportional hazard models
- Validation in NHANES
Main finding
As reported in the abstract
RA risk by dietary mineral intake
Hazard ratio (95% CI)
Highiron
0.804(0.687–0.940)
Highmagnesium
0.823(0.704–0.962)
Middlephosphorus
0.827(0.707–0.966)
Highphosphorus
0.794(0.679–0.928)
Middlecopper
0.819(0.702–0.955)
Highcopper
0.763(0.652–0.893)
Observational data: associations, not effects.
Further findings
Validation in NHANES
- Similar results were observed in NHANES, particularly iron, magnesium, phosphorus and copper
Original publication
Associations between dietary mineral intake and rheumatoid arthritis: evidence from UK Biobank and NHANES. Rheumatology (Oxford). Published 8 August 2025. doi:10.
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