Lipid metabolism dysregulation in rheumatoid arthritis: from multi-omics discovery to adjunctive therapy with conjugated linoleic acid
Authors' conclusion
These findings reveal lipid metabolism as a druggable axis, position dietary CLA as an adjunct to improve outcomes in RA
Study context
- Population
- Individuals with rheumatoid arthritis (RA), systemic lupus erythematosus, and controls; RA clinical cohort receiving conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs)599 samples
- Participants
- 443 individuals
Methodological detailsmulti-omics, collagen-induced arthritis mouse model, clinical validation cohort
- Multi-omics
- Collagen-induced arthritis mouse model
- Clinical validation cohort
Main finding
As reported in the abstract
- Multi-omics: comprehensive alterations in metabolic signatures (metabolism-related molecules, metabolites, metabolic pathways) in RA
- Lipid metabolism pathways, particularly linoleic acid metabolism, appear to play a significant regulatory role in RA progression
- Linoleic acid metabolism metabolites and molecules significantly associated with clinical phenotypes in RA
- Mouse model: Conjugated linoleic acid (CLA) reduced arthritis scores, swollen joint counts, histopathological scores and inflammatory levels
- RA cohort (n = 26): CLA supplementation accelerated reduction of inflammatory levels in patients on csDMARDs
Original publication
Lipid metabolism dysregulation in rheumatoid arthritis: from multi-omics discovery to adjunctive therapy with conjugated linoleic acid. Arthritis Res Ther. Published 19 May 2026. doi:10.
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