Infiltrations of plasma cells in synovium predict inadequate response to Adalimumab in Rheumatoid Arthritis patients
Authors' conclusion
Inadequate responses to adalimumab in RA patients were associated with increased plasma cell infiltrations in the synovium.
Study context
- Population
- Rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX) treated with adalimumab, synovial biopsy at baseline
- Participants
- 56 patients
- Exposure
- Non-responders vs responders to adalimumab at 12 weeks
- Non-respondern = 24
- Outcome
- Clinical and synovial biomarkers predicting poor response (failure to achieve ACR20) to adalimumab
- Follow-up
- 12 weeks
Methodological detailssingle-centre, multivariate logistic regression
- Single-centre
- Multivariate logistic regression
Main finding
As reported in the abstract
- Failed to achieve ACR20 with adalimumab: 24 (42.9%) of participants
- Non-responders exhibited higher infiltration of plasma cells in the synovium
- Presence of plasma cells an independent risk factor for inadequate response to adalimumab (multivariate logistic regression)
Observational data: associations, not effects.
Original publication
Infiltrations of plasma cells in synovium predict inadequate response to Adalimumab in Rheumatoid Arthritis patients. Arthritis Res Ther. Published 31 October 2024. doi:10.
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