Inflammation response criteria for rheumatoid arthritis based on the two-component disease activity score
Authors' conclusion
2C-DAS28 response correlates significantly with ultrasound-detected synovitis and is associated with improved clinical outcomes.
Study context
- Population
- Patients with rheumatoid arthritis (RA) at three stages of treatment progression, by DMARD prescribed
- Participants
- 1,051 / 989 / 301 / 161
- Comparison
- 3-month 2C-DAS28 responders vs non-responders; 2C-DAS28 response vs conventional response criteria
- Early RAn = 1,051
- Established RAn = 989
- Late RAn = 301
- Validationn = 161
- Outcome
- 2C-DAS28 thresholds defining inflammation response (remission or clinically meaningful reduction in disease activity), based on Boolean V.2.0 remission and CDAI response
- Follow-up
- 3 months
Methodological detailsROC analysis with Youden's J, independent validation cohort
- ROC analysis with Youden's J
- Independent validation cohort
Performance
As reported in the abstract
2C-DAS28 inflammation response thresholds
- 2C-DAS28<1.8
- Decrease in 2C-DAS28>1.7
Further findings
Correlation of 3-month 2C-DAS28 response with US synovitis (validation cohort)
- Synovial thickness, r (95% CI −0.47 to −0.04), p=0.037
- −0.25
- Power Doppler score, r (95% CI −0.52 to −0.04), p=0.042
- −0.28
- Conventional response criteria showed no significant correlation with synovitis scores
Disease activity at 6 months, 3-month 2C-DAS28 responders vs non-responders (discovery cohorts)
- Responders retained lower disease activity than non-responders
Original publication
Inflammation response criteria for rheumatoid arthritis based on the two-component disease activity score. RMD Open. Published 9 March 2026. doi:10.
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