Systemic sclerosis & Raynaud's
Increased serum soluble interleukin-2 receptor concentrations are linked to high-sensitivity troponin T and disease progression in systemic sclerosis
Authors' conclusion
sIL-2R concentrations reflect disease severity, particularly cardiac damage, and early disease progression, and suggest a potential role for disease and therapy monitoring.
Study context
- Population
- Patients with systemic sclerosis (SSc), clinical data at baseline and up to 48 months after
- Participants
- 315 patients
- Exposure
- dcSSc vs lcSSc; sIL-2R ≥900 U/ml vs lower
- dcSScn = 139
- lcSScn = 176reference
- Outcome
- Serum sIL-2R concentrations as biomarker in SSc and their association with hs-CRP, b2M and hs-TnT
Methodological detailslogistic regression, Kaplan-Meier method, Mantel-Cox proportional hazard models
- Logistic regression
- Kaplan-Meier method
- Mantel-Cox proportional hazard models
Main finding
As reported in the abstract
Serum sIL-2R concentrations
- sIL-2R correlation with b2M
- r=0.6161, p<0.001
- sIL-2R correlation with hs-CRP
- r=0.4091, p<0.001
- sIL-2R correlation with hs-TnT
- r=0.4548, p<0.001
- Increase in sIL-2R associated with cardiac involvement
- p=0.014
- Increase in sIL-2R associated with pulmonary involvement
- p=0.007
- Increase in sIL-2R associated with skin involvement
- p<0.001
Observational data: associations, not effects.
Further findings
| Outcome | Values | HR | P value |
|---|---|---|---|
| sIL-2R discrimination of normal vs pathological hs-TnT | sIL-2R AUC 0.87 · 95% CI 0.77-0.97 · P p<0.001 · sensitivity 80.0% · specificity 80.1% | ||
| Early disease progression, sIL-2R ≥900 U/mlLog-rank test and Mantel-Cox proportional hazard models | 2.21 | P = 0.001 |
sIL-2R in patients with clinical improvement
- sIL-2R concentration decreased
- P = 0.004
Original publication
Increased serum soluble interleukin-2 receptor concentrations are linked to high-sensitivity troponin T and disease progression in systemic sclerosis. Clin Exp Rheumatol. Published 24 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →