Incident Gout and Risk of First‐Time Acute Coronary Syndrome: A Prospective, Population‐Based Cohort Study in Sweden
Authors' conclusion
Patients with incident gout have a 44% increased risk of first-time ACS, higher in women than in men. This risk is largely explained by the underlying comorbidities, but there is still a modestly increased risk that may be due to gout-related factors.
Study context
- Population
- Primary and secondary care patients with incident gout (mean age 65.6 years; 67.4% male) and matched population controls, Swedish registers 2007–2017
- Participants
- 20,146 vs 83,517
- Exposure
- Incident gout vs matched population controls
- Goutn = 20,146
- Controlsn = 83,517reference
- Outcome
- First-time ACS
Methodological detailsmatched population controls, register-based, Cox regression adjusted for baseline comorbidities and dispensed prescriptions
- Matched population controls
- Register-based
- Cox regression adjusted for baseline comorbidities and dispensed prescriptions
Main finding
As reported in the abstract
Gout vs ControlsHazard ratio (95% CI)
Unadjusted
1.44(1.33–1.56)
Multivariable
1.15(1.06–1.25)
Observational data: associations, not effects.
Further findings
First-time acute coronary syndrome (ACS) by sex (unadjusted Cox regression)
- Gout vs controls, women: HR
- 1.64 (1.41-1.90) (95% CI)
- Gout vs controls, men: HR
- 1.36 (1.24-1.50) (95% CI)
- Unadjusted
First-time ACS, multivariable analysis (adjusted for baseline comorbidities and dispensed prescriptions)
- HR (95% CI); risk diminished but remained significant
- 1.15 (1.06-1.25)
First-time ACS, sensitivity analysis (no previously diagnosed comorbidity; 6,075 cases and 44,091 controls)
- Overall: HR (95% CI); risk similar
- 1.20 (1.01-1.44)
- Women: HR
- 1.34 (0.86-2.08) (95% CI)
- Men: HR
- 1.18 (0.97-1.44) (95% CI)
- Sensitivity analysis
Original publication
Incident Gout and Risk of First‐Time Acute Coronary Syndrome: A Prospective, Population‐Based Cohort Study in Sweden. Arthritis Care Res (Hoboken). Published 28 December 2022. doi:10.
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