Interleukin-37: associations of plasma levels and genetic variants in gout
Authors' conclusion
We demonstrated the up-regulation of IL-37 levels across the clinical phases of gout: asymptomatic hyperuricemia, intercritical, and chronic tophaceous gout compared to control.
Study context
- Population
- Controls, people with asymptomatic hyperuricemia and patients in various clinical phases of gout
- Participants
- 50 / 74 / 200 / 18 / 30
- Exposure
- Clinical phases of gout and asymptomatic hyperuricaemia vs controls with no history of primary hyperuricemia/gout
- Controln = 50reference
- Asymptomatic hyperuricemian = 74
- Intercritical goutn = 200
- Acute gouty flaren = 18
- Chronic tophaceous goutn = 30
- Outcome
- Plasma IL-37 levels (ELISA) and IL-37 genetic variants across clinical phases of gout
Methodological detailscase-control, genetic association
- Case-control
- Genetic association
Main finding
As reported in the abstract
Plasma IL-37 levels vs control
- Asymptomatic hyperuricemia vs Control: P = 0.045
- Intercritical gout vs Control: P = 0.001
- Chronic tophaceous gout vs Control: P = 0.021
- Acute gouty flare vs Control: P = 0.061
Observational data: associations, not effects.
Further findings
MAF
| Outcome | Chronic tophaceous gout | Control |
|---|---|---|
| rs3811045, rs3811046, rs3811047, rs3811048 MAF | 0.57 | 0.67 |
- rs2708959 over-presentation vs European population (MAF = 0.05) · gouty cohort vs European population
- P = 0.003
- rs2708959 over-presentation vs European population (MAF = 0.05) · vs European population
- 0.033
- rs2708959 over-presentation vs European population (MAF = 0.05) · not over-presented; MAF 0.08
- 0.17
- rs2708959 over-presentation vs European population (MAF = 0.05) · not over-presented; MAF 0.05
- 0.71
IL-37 genetic variants identified
- Genetic variants of IL-37 identified (8 intron, 7 non-synonymous)
- 15
rs3811045, rs3811046, rs3811047, rs3811048 MAF
- Underrepresented in tophaceous gout vs European MAF 0.70-0.71, but not vs control
Original publication
Interleukin-37: associations of plasma levels and genetic variants in gout. Arthritis Res Ther. Published 18 October 2023. doi:10.
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