All-cause and specific mortality in patients with gout: A systematic review and meta-analysis
Pooled result · Overall mortalityResult — go to the resultHazard ratio 1.23 95 % CI 1.13–1.35Authors' conclusion
The findings from our meta-analysis indicate that gout is associated with an increased risk of all-cause mortality, as well as mortality related to cardiovascular disease, infections, and digestive system diseases.
Study context
- Population
- Published cohort studies on gout and mortality (PubMed, EMBASE, Cochrane Library, inception to September 2022)
- Participants
- 14,854,490 participants11 cohort studies
- Comparison
- Gout vs no gout
- Outcome
- All-cause mortality
Methodological detailsNOS quality assessment, funnel plots and Egger's test for publication bias
- NOS quality assessment
- Funnel plots and Egger's test for publication bias
Pooled result
Overall mortality · follow-up 1.66-16 years
Hazard ratio
1.23
95 % CI 1.13–1.35
P < 0.001
Goutvs no gout
HR 1.23 (95 % CI 1.13–1.35); P < 0.001
As reported in the abstract
Further pooled results
CVD mortality
| HR (95 % CI) | P value | ||
|---|---|---|---|
| GoutI2=98.5 % | 1.29 (1.13–1.48) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Infection mortality
| HR (95 % CI) | P value | ||
|---|---|---|---|
| GoutI2=88.5 % | 1.24 (1.04–1.47) | P = 0.019 | |
| 0.512Hazard ratio (log scale) |
Digestive system disease mortality
| HR (95 % CI) | P value | ||
|---|---|---|---|
| GoutI2=91.7 % | 1.42 (1.13–1.80) | P = 0.003 | |
| 0.512Hazard ratio (log scale) |
Sensitivity and subgroup analyses; publication bias
- Sensitivity and subgroup analysis support the findings, and publication bias was not evident
Original publication
All-cause and specific mortality in patients with gout: A systematic review and meta-analysis. Semin Arthritis Rheum. Published 7 October 2023. doi:10.
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