Postoperative complications and outcomes after surgical treatment for tophaceous gout: A systematic review and meta-analysis
Authors' conclusion
Surgical treatment for tophaceous gout is associated with measurable postoperative risks, particularly infection and overall complications.
Study context
- Population
- Patients undergoing surgical treatment for tophaceous gout; PubMed, Embase, Web of Science and Cochrane Library searched from inception to March 25, 202618 retrospective studies
- Outcome
- Postoperative infection, delayed wound healing and recurrence
Methodological detailsrandom-effects single-arm meta-analysis
- Random-effects single-arm meta-analysis
Pooled result
As reported in the abstract
Pooled event rates of primary outcomes
Postoperative infection, pooled rate
11.3%
95% CI 8.0%–15.7%
Delayed wound healing, pooled rate
9.9%
95% CI 5.1%–18.2%
Recurrence, pooled rate
8.5%
95% CI 4.7%–14.9%
Further pooled results
Pooled event rates of secondary outcomes
- Reoperation, pooled rate
- 9.7% (95% CI 5.5%-16.7%)
- Amputation, pooled rate
- 3.7% (95% CI 2.0%-6.8%)
- Overall complications, pooled rate
- 24.0% (95% CI 14.0%-38.1%)
Subgroup analyses
- Significant subgroup differences only for infection by anatomic site and intervention type
Sensitivity analyses
- Pooled estimates were robust
Original publication
Postoperative complications and outcomes after surgical treatment for tophaceous gout: A systematic review and meta-analysis. Semin Arthritis Rheum. Published 30 June 2026. doi:10.
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