Association between blood heavy metal concentrations and hyperuricemia: A systematic review and meta-analysis
Authors' conclusion
In conclusion, this study demonstrates a significant positive association between blood lead levels and the risk of HU. No significant association is found between blood levels of cadmium, manganese, and mercury and the risk of HU.
Study context
- Population
- Studies of blood heavy metal concentrations and hyperuricemia; PubMed, EMBASE, Web of Science and Cochrane Library searched up to June 202419 studies
- Comparison
- Blood heavy metal concentrations and risk of hyperuricemia
- Outcome
- Association between blood heavy metal concentrations and hyperuricemia (pooled OR)
Methodological detailsrandom-effects or fixed-effects model, sensitivity analysis, funnel plots and Egger's test
- Random-effects or fixed-effects model
- Sensitivity analysis
- Funnel plots and Egger's test
Pooled result
As reported in the abstract
Risk of hyperuricemia by blood heavy metal level
Odds ratio (95% CI)P value
Blood lead levels
1.88(1.22–2.92)
P < 0.005Blood cadmium levels
1.31(0.68–2.52)
Blood manganese levels
1.04(0.88–1.22)
Blood mercury levels
1.55(0.70–3.44)
Original publication
Association between blood heavy metal concentrations and hyperuricemia: A systematic review and meta-analysis. Joint Bone Spine. Published 31 July 2026. doi:10.
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