Annual gout flare frequency as a marker of sustained cardiovascular risk: a clinical threshold for risk stratification
Authors' conclusion
Annual gout flare frequency is a graded marker of sustained cardiovascular risk.
Study context
- Population
- Adults with a first EHR-recorded treated gout flare in 2017, TriNetX Global Collaborative Network13,179 high vs low
- Participants
- 44,705 adults
- Exposure
- High and moderate vs low gout flares/year
- Outcome
- Modified MACE:
- MI
- Stroke
- HF
- Follow-up
- 7 years
Methodological details1:1 propensity score matching, 12-month landmark exposure window, TriNetX Global Collaborative Network
- 1:1 propensity score matching
- 12-month landmark exposure window
- TriNetX Global Collaborative Network
Main finding
As reported in the abstract
Modified MACE
Each group vs lowRelative risk (95% CI)
High
1.45(1.37–1.53)
Moderate
1.24(1.15–1.33)
Observational data: associations, not effects.
Further findings
| Outcome | HR |
|---|---|
| HFHigh vs Low | 1.27 |
| HFModerate vs Low | 1.17 |
| Stroke and MI (each) · 7 yearsHigh vs Low · stroke significant from 3 years | 1.28 |
| MACE, sensitivity analysis with stricter flare definition (NSAIDs excluded) · 7 yearsHigh vs Low | 1.19 |
| MACE, sensitivity analysis with stricter flare definition (NSAIDs excluded) · 7 yearsModerate vs Low | 1.12 |
Stroke and MI (each) · 7 years
- Elevated only in the high group
Original publication
Annual gout flare frequency as a marker of sustained cardiovascular risk: a clinical threshold for risk stratification. Rheumatology (Oxford). Published 16 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →