Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care
Authors' conclusion
Gout-specific, comorbid and sociodemographic factors were associated with change in HRQOL over a 3-year period, highlighting people at risk of worse outcomes who could be targeted for interventions.
Study context
- Population
- UK adults with a diagnosis of gout registered with 20 general practicesresponded at baseline
- Participants
- 1,184 adults
- Outcome
- Change in HRQOL: Gout Impact Scale (GIS; 0-100), PF-10 (0-100) and HAQ-DI (0-3)
- Follow-up
- 3 years
Methodological detailsprimary care, 20 general practices, postal questionnaires, linear mixed modelling, Responders: 818, 721, 696 and 605 at 6, 12, 24 and 36 months, Adjusted baseline response 65.6%; 990 (83.6%) male; mean age 65.6 years (SD 12.5)
- Primary care
- 20 general practices
- Postal questionnaires
- Linear mixed modelling
- Responders: 818, 721, 696 and 605 at 6, 12, 24 and 36 months
- Adjusted baseline response 65.6%; 990 (83.6%) male; mean age 65.6 years (SD 12.5)
Main finding
As reported in the abstract
Factors associated with change in HRQOL over 3 years
- Flare frequency (five or more flares) associated with worse health-related quality of life (HRQOL) (Gout Impact Scale (GIS) subscales, PF-10)
- P ≤ 0.05
- Oligo/polyarticular flares associated with worse HRQOL (GIS subscales, PF-10, HAQ Disability Index (HAQ-DI))
- P ≤ 0.05
- Worse pain associated with worse HRQOL (GIS subscales, PF-10, HAQ-DI)
- P ≤ 0.05
- Body pain associated with worse HRQOL (GIS subscales, PF-10, HAQ-DI)
- P ≤ 0.05
- More severe depression associated with worse HRQOL (GIS subscales, PF-10, HAQ-DI)
- P ≤ 0.05
- Older age associated with worse generic HRQOL (PF-10)
- P ≤ 0.05
- Being female associated with worse generic HRQOL (PF-10, HAQ-DI)
- P ≤ 0.05
- BMI associated with worse generic HRQOL (HAQ-DI)
- P ≤ 0.05
Observational data: associations, not effects.
Original publication
Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care. Rheumatology (Oxford). Published 21 December 2022. doi:10.
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