Title: Impact of Coexisting Gout on Disease Activity in Rheumatoid Arthritis: Data from the Ontario Best Practices Research Initiative (OBRI)
Authors' conclusion
In this large real-world RA cohort, coexisting gout was uncommon and associated with traditional gout risk factors but did not statistically influence oral GC use or RA treatment target attainment.
Study context
- Population
- Rheumatoid arthritis (RA) patients enrolled in the Ontario Best Practices Research Initiative, a multicentre real-world cohort across Ontario, Canada
- Participants
- 3,703 RA patients
- Exposure
- RA patients with vs without coexisting gout
- COEXISTING GOUTn = 113
- Outcome
- Prevalence of coexisting gout
Methodological detailsmulticentre real-world cohort, multivariable logistic regression, mixed-effects logistic regression, adjusting for prespecified confounders
- Multicentre real-world cohort
- Multivariable logistic regression
- Mixed-effects logistic regression
- Adjusting for prespecified confounders
Main finding
As reported in the abstract
Coexisting gout among 3,703 RA patients
113
3.1%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Oral GC use · 12-monthsAfter adjustment; not significantly associated | OR for oral GC use 1.73 (95% CI 0.96–3.13) | |
| Attainment of CDAI low disease activity/remission · by 24-monthsAfter adjustment; not significantly associated | OR for attainment of CDAI low disease activity/remission 1.19 (95% CI 0.72–1.97) | |
| 0.20.5125Ratio (log scale) |
| Outcome | COEXISTING GOUT | WITHOUT GOUT |
|---|---|---|
| CDAI score · baselineSimilar between patients with and without gout | 18.3 ± 12.5 | 20.2 ± 13.5 |
| CDAI score · 12-monthsSimilar between patients with and without gout | 10.9 ± 9.8 | 11.0 ± 10.4 |
Factors associated with coexisting gout
- Older age, OR per year
- 1.05
- Obesity, OR
- 1.67
- Cardiovascular disease or hypertension, OR
- 1.95
- Diuretic use, OR
- 1.68
- Female sex (inversely associated), OR
- 0.31
Characteristics of patients with coexisting gout
- Mean (SD) age, years
- 66.1 (8.7)
- Female
- 52.2%
Original publication
Title: Impact of Coexisting Gout on Disease Activity in Rheumatoid Arthritis: Data from the Ontario Best Practices Research Initiative (OBRI). Joint Bone Spine. Published 31 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →