Factors affecting the discrepancy between patient and physician global assessment in early rheumatoid arthritis: The Ontario Best Practices Research Initiative
Authors' conclusion
Significant PtGA-PhGA discrepancy was found in approximately one-quarter of early RA patients. In the majority of these patients, PtGA was higher than PhGA. The main predictors of PtGA and PhGA remained the same after one year.
Study context
- Population
- Patients with early rheumatoid arthritis (RA) (mean disease duration 0.3 years) from the Ontario Best Practices Research Initiative (OBRI)analysed
- Participants
- 531 patients
- Outcome
- Prevalence of PtGA–PhGA discordance (absolute PtGA-PhGA ≥30) and factors affecting it
- Follow-up
- Enrolment and after one year
Methodological detailslinear regression analysis, multivariable regression analysis
- Linear regression analysis
- Multivariable regression analysis
Main finding
As reported in the abstract
Discordance prevalence at enrolment
22.4%
Discordance prevalence after one year
20.3%
Observational data: associations, not effects.
Further findings
Factors associated with patient global assessment (PtGA) (multivariable regression) · enrolment and 1-year follow-up
- Higher PtGA significantly associated with higher pain score, tender joint counts (TJC28), ESR and fatigue at enrolment and 1-year follow-up; with higher swollen joint counts (SJC28) only at enrolment
Factors associated with PhGA (multivariable regression) · enrolment and 1-year follow-up
- Similar associations as for PtGA, except fatigue not a significant factor at one year
Factors associated with PtGA-PhGA discrepancy (multivariable analysis) · enrolment and 1-year follow-up
- Higher discrepancy associated with lower SJC28 and higher pain score at enrolment
- Higher discrepancy associated with lower SJC28 and higher pain and fatigue score at 1-year follow-up
Original publication
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