Crystalline silica exposure in patients with rheumatoid arthritis and systemic sclerosis: a nationwide cross-sectional survey
Authors' conclusion
The lifetime SiO2 exposure gap between RA and SSc patients and controls was substantially due to occupational exposure. In both diseases, men had higher exposure scores than women.
Study context
- Population
- General population panel sampled from the French rolling census and unselected patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA)
- Participants
- 100 / 97 / 2,911
- Exposure
- Patients with SSc and RA vs matched general-population controls
- SScn = 100
- RAn = 97
- Controlsn = 2,911reference
- Outcome
- Lifetime SiO2 exposure: global (GES), occupational (OES) and non-occupational (NOES) exposure scores
Methodological detailsnationwide, matched controls (up to four, by age group, sex and tobacco consumption), questionnaire development and validation
- Nationwide
- Matched controls (up to four, by age group, sex and tobacco consumption)
- Questionnaire development and validation
Main finding
As reported in the abstract
Global exposure score (GES), patients vs matched controls
- SSc vs Controls: P = 0.001
- RA vs Controls: P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Occupational exposure score (OES), patients vs matched controlsSSc vs Controls · higher OES in patients | P < 0.0001 |
| Occupational exposure score (OES), patients vs matched controlsRA vs Controls · higher OES in patients | P < 0.0001 |
GES, men vs women
- Men had higher GES than women in SSc
- P < 0.0001
- Men had higher GES than women in RA
- P = 0.002
- Men had higher OES than women in SSc and RA
- P < 0.0001
- NOES did not differ between men and women
SSc subgroups by sex vs controls
- Men with SSc had higher GES than controls
- P < 0.0001
- Men and women with SSc had higher OES than controls
- P < 0.0001
RA subgroups by sex vs controls
- Men with RA: higher GES than controls
- P = 0.00521
- Men with RA: higher OES than controls
- P < 0.0001
- Women with RA: higher GES than controls
- P < 0.0001
- Women with RA: higher OES than controls
- P < 0.0001
- Women with RA had higher NOES than controls
- P = 0.045
Original publication
Crystalline silica exposure in patients with rheumatoid arthritis and systemic sclerosis: a nationwide cross-sectional survey. Rheumatology (Oxford). Published 2 December 2022. doi:10.
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