Impact of Clinical Association Between Gout and Dementia: A Nationwide Population‐Based Cohort Study in Korea
Main finding · Overall dementiaResult — go to the resultHazard ratio 0.79 95% CI 0.62–1.00Authors' conclusion
Gout decreased the risk of incident Alzheimer's disease-type dementia, especially in elderly patients.
Study context
- Population
- Gout patients and age- and sex-matched controls from the NHIS-National Sample Cohort database, Koreamatched cohort
- Participants
- 5,052 vs 25,260
- Exposure
- Gout vs age- and sex-matched controls
- Goutn = 5,052
- Controlsn = 25,260reference
- Outcome
- Incidence and risk of dementia
Methodological detailsnationwide, population-based, age- and sex-matched, NHIS-National Sample Cohort database
- Nationwide
- Population-based
- Age- and sex-matched
- NHIS-National Sample Cohort database
Main finding
Overall dementia
Hazard ratio
0.79
95% CI 0.62–1.00
Events by group
Gout
81
events
Controls
558
events
Goutvs Controls
HR 0.79 (95% CI 0.62–1.00)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Alzheimer's diseaseAdjusted for age, sex, household income and comorbidities | 0.73 (0.54–0.98) | |
| Overall dementia (subgroup: elderly male) | 0.71 (0.52–0.97) | |
| Alzheimer's disease (subgroup: elderly male) | 0.67 (0.46–0.97) | |
| Vascular dementia (subgroup: nonelderly male)Age- and sex-adjusted | 2.31 (1.02–5.25) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Impact of Clinical Association Between Gout and Dementia: A Nationwide Population‐Based Cohort Study in Korea. Arthritis Care Res (Hoboken). Published 18 December 2022. doi:10.
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