Improved outcomes in rheumatoid arthritis with obesity after a weight loss intervention: randomized trial
- recruitment terminated early
- Recruitment terminated early
Authors' conclusion
Obese RA patients on the diet intervention achieved weight loss. There were significant between group improvements for RAPID3, adiponectin and leptin levels, and positive trends for DAS28 and HAQ-DI.
Study context
- Population
- Obese RA patients (BMI ≥ 30) with DAS (DAS28) ≥ 3.2 and power Doppler synovitis
- Participants
- 40 patients
- Comparison
- Weight loss diet intervention vs control
- Diet interventionn = 20
- Controln = 20reference
- Primary endpoint
- Co-primary: change in DAS28 and power Doppler US (power Doppler ultrasound (PDUS))-34
- Follow-up
- 12 weeks
Methodological detailsproof-of-concept, single-blind, 12-week
- Proof-of-concept
- Single-blind
- 12-week
Primary result
As reported in the abstract
Co-primary: change in DAS28
- DAS28 within diet group, 5.2 to 4.2
- P < 0.001
- Between-group difference in DAS28 change
- −0.51 [95% CI −1.01, 0.00], P = 0.056
Further findings
| Outcome | Diet intervention | Control | P value |
|---|---|---|---|
| Weight loss · 12 weeks | average 9.5 kg/patient | 0.5 kg | P < 0.001 |
Co-primary: PDUS-34, between-group difference · 12 weeks
- Ultrasound measures and multi-biomarker disease activity score did not differ between groups; PDUS-34 between-group difference
- −2.0 [95% CI −7.00, 3.1], P = 0.46
- Intent-to-treat
RAPID3, serum leptin and serum adiponectin
- RAPID3 improved, leptin decreased and adiponectin increased significantly within diet group and between groups
- all P < 0.03
HAQ-Disability Index (HAQ-DI)
- HAQ-DI improved significantly within diet group
- P < 0.04
- HAQ-DI between groups
- P = 0.065
Original publication
Improved outcomes in rheumatoid arthritis with obesity after a weight loss intervention: randomized trial. Rheumatology (Oxford). Published 28 May 2022. doi:10.
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