Weight change and longitudinal disease activity in rheumatoid arthritis: A real-world cohort study
Main finding · DAS28-CRP, weight-change-by-time interactionResult — go to the resultInteraction (per 5% weight change) −0.004 units/year 95% CI −0.026 to 0.018Authors' conclusion
In RA with predominantly class I obesity, we did not observe a clear association between routine clinical care weight change and improved inflammatory disease activity.
Study context
- Population
- Adults with rheumatoid arthritis (RA) and obesity (BMI≥30kg/m²), Montpellier University Hospitalwith estimable weight change
- Participants
- 106 adults
- Exposure
- Regression-based % weight change over follow-up (per 5%) and DAS28-CRP trajectories
- ≥5% lossn = 24
- Stablen = 64reference
- ≥5% gainn = 18
- Outcome
- Repeated DAS28-CRP (weight change-by-time interaction)
Methodological detailssingle-centre, mixed-effects models, multiple imputation
- Single-centre
- Mixed-effects models
- Multiple imputation
Main finding
DAS28-CRP, weight-change-by-time interaction
Interaction (per 5% weight change)
−0.004 units/year
95% CI −0.026 to 0.018
Weight change
interaction (per 5% weight change) −0.004 units/year (95% CI −0.026 to 0.018)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Remission (DAS28-CRP<2.6) over time
| Interaction OR per 5% (95% CI) | ||
|---|---|---|
| Weight change | 1.01 (0.96–1.06) | |
| 0.512Interaction OR per 5% (log scale) |
Low disease activity (≤3.2) over time
| Interaction OR per 5% (95% CI) | ||
|---|---|---|
| Weight change | 1.00 (0.94–1.07) | |
| 0.512Interaction OR per 5% (log scale) |
| Outcome | Difference (units/year) (95% CI) | |
|---|---|---|
| DAS28-CRP, categorical weight change (sensitivity analysis)≥5% gainvs StableSensitivity analyses were consistent | −0.003 (−0.158 to 0.153) | |
| −0.2−0.100.10.2Difference, units/year (linear scale) |
| Outcome | Difference (units/year) (95% CI) |
|---|---|
| DAS28-CRP, categorical weight change (sensitivity analysis)≥5% loss vs Stable · Sensitivity analyses were consistent | +0.021 (−0.076 to 0.119) |
DAS28-CRP components
- No signal observed for DAS28-CRP components
Original publication
Weight change and longitudinal disease activity in rheumatoid arthritis: A real-world cohort study. Joint Bone Spine. Published 19 September 2026. doi:10.
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