Persistence of power Doppler ultrasonography-detected synovitis over 1 year of follow-up predicts poor prognosis in rheumatoid arthritis in clinical remission: the SONORE prospective longitudinal study
Authors' conclusion
Persistent PDUS during follow-up, rather than at baseline, predicted worse outcome at 1 year
Study context
- Population
- Patients with rheumatoid arthritis (RA) (2010 ACR-EULAR criteria) in clinical remission (DAS28<2.6 without clinically active synovitis)
- Participants
- 115 patients
- Exposure
- Persistent PDUS as predictor of relapse or radiographic progression
- Outcome
- Relapse or radiographic progression (≥1 point increase in mTSS)
- Follow-up
- 1 year
Methodological detailsindependent ultrasonography investigator, US every 3 months for 1 year, univariate and multivariate Cox regression
- Independent ultrasonography investigator
- US every 3 months for 1 year
- Univariate and multivariate Cox regression
Main finding
As reported in the abstract
Predictors of relapse/radiographic progression (multivariate)
- Persistent PDUS, HR
- 2.98
- Persistent PDUS, p
- p=0.014
- Increase in DAS28-CRP at visit before relapse, HR
- 4.36
- Increase in DAS28-CRP at visit before relapse, p
- p=0.004
Observational data: associations, not effects.
Further findings
PDUS detection over follow-up (of 115 patients) · baseline, months 3, 6, 9, 12
- Baseline
- 75 (65.2%)
- Month 3
- 66
- Month 6
- 60
- Month 9
- 46
- Month 12
- 29
- Persistent PDUS
- 58 (50.4%)
Relapse and radiographic progression · 1 year
- Relapse
- 22/85 (25.9%)
- Radiographic progression
- 12 (14.1%)
Original publication
Persistence of power Doppler ultrasonography-detected synovitis over 1 year of follow-up predicts poor prognosis in rheumatoid arthritis in clinical remission: the SONORE prospective longitudinal study. RMD Open. Published 17 September 2024. doi:10.
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