A link between CD8+CD27-CD28- T cells expressing chemerin chemokine-like receptor 1 and rheumatoid arthritis
Authors' conclusion
Our results suggest that CMKLR1 expression in T cells may be involved in RA pathogenesis through modulation of TNF-α expression and cell migration.
Study context
- Population
- Patients with rheumatoid arthritis (RA) or OA and healthy individuals (peripheral blood and synovial fluid)
- Comparison
- RA vs OA and healthy individuals
- Outcome
- Expression and role of CMKLR1 in T cells of patients with RA
Methodological detailsflow cytometry, Transwell migration assay, ELISA
- Flow cytometry
- Transwell migration assay
- ELISA
Main finding
As reported in the abstract
- CMKLR1 preferentially expressed in CD27-CD28- T cell subsets
- CMKLR1 surface levels reduced by stimulation with anti-CD3 antibody or chemerin
- Correlation between CMKLR1+CD8+CD27-CD28- T cell frequency and DAS28 in RA
- Chemerin up-regulated and CMKLR1 inhibitor down-regulated TNF-α expression in CD8+CD27-CD28- T cells (half of which express CMKLR1 on average)
- Chemerin induced migration of CD8+CD27-CD28- T cells
- Reduced CMKLR1+CD27-CD28- T cell levels in RA synovial fluid vs blood, with a few exceptions
Original publication
A link between CD8+CD27-CD28- T cells expressing chemerin chemokine-like receptor 1 and rheumatoid arthritis. Clin Exp Rheumatol. Published 22 May 2022. doi:10.
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