Substantive Similarities Between Synovial Fluid and Synovial Tissue T cells in Inflammatory Arthritis Via Single‐Cell RNA and T Cell Receptor Sequencing
Authors' conclusion
Our results suggest that T cells migrate and equilibrate between the SF and ST and maintain similar phenotypes in both sites.
Study context
- Population
- Patients with inflammatory arthritis
- Participants
- 6 patients
- Comparison
- Memory T cells from paired synovial fluid (SF) vs synovial tissue (ST)
- Outcome
- Similarity of SF and ST T cells in TCR repertoire and T cell subset composition
Methodological detailspaired samples, single-cell RNA sequencing, single-cell T cell receptor (TCR) sequencing
- Paired samples
- Single-cell RNA sequencing
- Single-cell TCR sequencing
Main finding
As reported in the abstract
Share of SF CD8+ TCR repertoire shared with ST (median)
49%
Share of SF CD8+ TCR repertoire shared with blood
20%
Share of ST CD8+ TCR repertoire shared with SF
47%
Share of ST CD8+ TCR repertoire shared with blood
25%
Original publication
Substantive Similarities Between Synovial Fluid and Synovial Tissue T cells in Inflammatory Arthritis Via Single‐Cell RNA and T Cell Receptor Sequencing. Arthritis Rheumatol. Published 27 August 2024. doi:10.
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