Plasma haem oxygenase-1 may represent a first-in-class biomarker of oxidative stress in rheumatoid arthritis
Authors' conclusion
In eRA, plasma levels of HO-1 were increased and correlated with disease and radiographic progression.
Study context
- Population
- Patients with early rheumatoid arthritis (RA) and active established RA, and healthy controls
- Participants
- 80 / 20 / 35
- Exposure
- Plasma HO-1 in early RA and established RA vs healthy controls
- Early rheumatoid arthritis (eRA)n = 80
- Established rheumatoid arthritis (esRA)n = 20
- Controlsn = 35reference
- Outcome
- Plasma HO-1 as biomarker of oxidative stress and its association with disease activity (DAS28-CRP, CDAI) and radiographic progression (total Sharp score)
- Follow-up
- 2 years
Methodological detailsprospective, 2-year serial follow-up, paired plasma and synovial fluid samples
- Prospective
- 2-year serial follow-up
- Paired plasma and synovial fluid samples
Main finding
As reported in the abstract
Plasma HO-1 levels · baseline
Observational data: associations, not effects.
Further findings
Correlation between synovial and plasma HO-1 levels
- Strong, linear correlation (r)
- 0.75, p < 0.001
Plasma HO-1 with treatment
- HO-1 plasma levels decreased with treatment
Original publication
Plasma haem oxygenase-1 may represent a first-in-class biomarker of oxidative stress in rheumatoid arthritis. Scand J Rheumatol. Published 17 September 2024. doi:10.
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