Cartilage destruction in early rheumatoid arthritis patients correlates with CD21−/low double-negative B cells
Authors' conclusion
Cartilage destruction in eRA patients was associated with an expanded proportion of CD21-/low DN B cells in PB. The subset was also expanded in SF from established RA patients and expressed RANKL.
Study context
- Population
- Newly diagnosed early rheumatoid arthritis (RA) patients and age- and sex-matched healthy donors; Synovial fluid (SF) from patients with established RA
- Participants
- 76 vs 28
- Exposure
- Early RA patients vs age- and sex-matched healthy donors
- Early RA (eRA)n = 76
- Healthy donorsn = 28reference
- Outcome
- B cell subsets in PB and association with clinical factors
Methodological detailsage- and sex-matched healthy donors, flow cytometry
- Age- and sex-matched healthy donors
- Flow cytometry
Main finding
As reported in the abstract
- eRA vs healthy donors: elevated frequency of naïve CD21+ B cells in peripheral blood (PB)
- eRA: lower frequencies of memory CD21+CD27+ subsets and CD21-/low CD27+IgD+ subset
- Only CD21-/low double-negative (DN) (CD27-IgD-) B cells associated with clinical factors: linked with joint space narrowing score (cartilage destruction)
Observational data: associations, not effects.
Further findings
CD21-/low DN B cells in SF from established RA
- Expanded in SF and expressed RANKL
Original publication
Cartilage destruction in early rheumatoid arthritis patients correlates with CD21−/low double-negative B cells. Arthritis Res Ther. Published 15 January 2024. doi:10.
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