Multiple morbidities are associated with serious infections in patients with rheumatoid arthritis
Authors' conclusion
Several morbidities are associated with an increased risk for SI.
Study context
- Population
- Adults with incident rheumatoid arthritis (RA) from 1999 through 2014, follow-up through 202170 % female, mean age 56 years
- Participants
- 911 adults
- Exposure
- Each of 55 comorbidities vs its absence
- Outcome
- Serious infection (SI)
Methodological detailsconditional frailty models, Model 1 adjusted for age, sex, calendar year, Model 2 additionally adjusted for RABBIT Risk Score of Infections, Model 3 additionally adjusted for Mayo serious infection (SI) Risk Score
- Conditional frailty models
- Model 1 adjusted for age, sex, calendar year
- Model 2 additionally adjusted for RABBIT Risk Score of Infections
- Model 3 additionally adjusted for Mayo SI Risk Score
Main finding
As reported in the abstract
SI risk by comorbidity
- SI incidence (293 SI among 155 patients, 17 %)
- 3.9 SI per 100 person-years
- Morbidities with significantly increased SI risk, Model 1
- 27 of 55
- Morbidities with significantly increased SI risk, Model 2
- 11
- Morbidities with significantly increased SI risk, Model 3
- 23
- SI risk increase per morbidity, three models
- 11-16 %
Observational data: associations, not effects.
Safety
- Fatal SI
- 18
Original publication
Multiple morbidities are associated with serious infections in patients with rheumatoid arthritis. Semin Arthritis Rheum. Published 15 January 2024. doi:10.
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