Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites
Authors' conclusion
The breakdown of immune tolerance mediated by reduced Tfr cells was associated with the altered gut microbiotas and their metabolites implying the possible mechanism of RA pathogenesis from the perspective of microecology-metabolism-immune.
Study context
- Population
- New-onset rheumatoid arthritis (RA) patients and healthy controls, Second Hospital of Shanxi Medical University, January 2022 to June 2022
- Participants
- 32 vs 17
- Comparison
- New-onset RA vs healthy controls
- RAn = 32
- Healthy controls (HCs)n = 17reference
- Outcome
- Gut microbiotas and their metabolites in RA and their association with Tfr cell-mediated immune tolerance
Methodological detailssingle-centre, 16S rDNA sequencing, metabolomic profiling, flow cytometry
- Single-centre
- 16S rDNA sequencing
- Metabolomic profiling
- Flow cytometry
Main finding
As reported in the abstract
- Ruminococcus 2 as potential biomarker of RA, AUC
- 0.782
- Ruminococcus 2 AUC 95% CI
- 0.636-0.929
- Ruminococcus 2 AUC P
- P = 0.001
- Differential metabolites identified, in four main pathways related to RA
- 11
- Arachidonic acid as potential biomarker of RA, AUC
- 0.724
- Arachidonic acid AUC 95% CI
- 0.595-0.909
- Arachidonic acid AUC P
- P = 0.038
Observational data: associations, not effects.
Original publication
Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites. Arthritis Res Ther. Published 13 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →