Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance
Authors' conclusion
Altered Trp-Kyn metabolism might contribute to the pathogenesis of RA.
Study context
- Population
- New-onset rheumatoid arthritis (RA) patients and healthy controls
- Participants
- 29 vs 19
- Comparison
- New-onset RA vs healthy controls
- RAn = 29
- Healthy controls (HCs)n = 19reference
- Outcome
- Serum Trp metabolites and RA-HC classification model
Methodological detailstargeted quantitative tryptophan (Trp) metabolomics, machine learning classification model
- Targeted quantitative Trp metabolomics
- Machine learning classification model
Main finding
As reported in the abstract
- 7 differential serum Trp metabolites, all decreased in RA vs HCs
- P < 0.05
- Trp-Kyn pathway downregulated in RA
- P < 0.05
- IDO1 (key Trp-Kyn enzyme) reduced in RA
- P < 0.05
- RA-HC classification model from 4 Trp-Kyn metabolites (Trp, xanthurenic acid (XA), cinnabarinic acid (CA), kynurenic acid (KynA)): AUC
- 0.951 (95% CI 0.897-1.000)
Observational data: associations, not effects.
Original publication
Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance. Arthritis Res Ther. Published 5 July 2025. doi:10.
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