Prognostic value of serum protein electrophoresis constituents for arthritis development in anti-citrullinated protein antibody-positive patients with musculoskeletal pain
Authors' conclusion
SPE does not add prognostic value for arthritis development in ACPA-positive patients with musculoskeletal pain.
Study context
- Population
- ACPA-positive patients with musculoskeletal pain but no baseline arthritis
- Participants
- 82 patients
- Exposure
- Patients who developed arthritis vs those who did not
- Developed arthritisn = 39
- Outcome
- Arthritis development, as judged by clinical examination
- Follow-up
- Median 72 months (IQR 57-81 months)
Methodological detailsCox regression
- Cox regression
Main finding
As reported in the abstract
Arthritis development · median 72 months follow-up
Hazard ratio (95% CI)P value
Elevated baseline haptoglobin
2.53(1.32–4.85)
P = 0.005Elevated baseline orosomucoid
2.63(1.09–6.31)
P = 0.03- Progressed to arthritis
- 39/82 (48%)
Observational data: associations, not effects.
Further findings
Baseline serum protein electrophoresis (SPE) constituent levels, arthritis vs no arthritis · median baseline
- Median orosomucoid and α1-anti-trypsin higher in those who developed arthritis
- P = 0.04
- Median albumin significantly lower in those who developed arthritis
- P = 0.03
- Immunoglobulin levels did not differ between the groups
Original publication
Prognostic value of serum protein electrophoresis constituents for arthritis development in anti-citrullinated protein antibody-positive patients with musculoskeletal pain. Scand J Rheumatol. Published 12 January 2024. doi:10.
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