Associations of galectin-3 levels with measures of vascular disease in patients with rheumatoid arthritis
Authors' conclusion
In our cohort of RA patients without clinical CVD, higher serum galectin-3 levels were independently associated with higher levels of aortic inflammation, but not CAC score or MFR.
Study context
- Population
- Rheumatoid arthritis (RA) patients without clinical cardiovascular disease (CVD) (mean age 57; 82 % women, 45 % Hispanic; median RA duration 6.8 years; 75 % seropositive)
- Participants
- 124 patients
- Outcome
- Associations of serum galectin-3 levels with CAC score, aortic inflammation (aortic SUV on FDG PET/CT) and MFR
Methodological detailsgeneralized linear models, univariable and multivariable analysis
- Generalized linear models
- Univariable and multivariable analysis
Main finding
As reported in the abstract
Association of galectin-3 level with subclinical vascular disease measures
- Higher galectin-3 associated with higher aortic standardized uptake values (SUV), multivariable, ß Coefficient
- 0.1786
- Multivariable association with aortic SUV, p value
- p value=0.002
Observational data: associations, not effects.
Further findings
Cohort measures
- Median galectin-3 level (ng/mL)
- 8.54
- Median aorta SUV
- 2.59
- Mean myocardial flow reserve (MFR)
- 2.86
- Median coronary artery calcium (CAC) score
- 0
- Median CDAI
- 16
- On prednisone
- 33 %
- On DMARDs
- 89 %
Original publication
Associations of galectin-3 levels with measures of vascular disease in patients with rheumatoid arthritis. Semin Arthritis Rheum. Published 15 January 2024. doi:10.
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