Truth unveiled by time and the marbled definition of D2T-RA: retrospective analysis on the persistence of the difficult-to-treat status among refractory RA patients
Authors' conclusion
The application of a temporal criterion allowed for the selection of a subgroup of pD2T-RA patients who differ from those who meet the definition of D2T-RA only episodically. Chronic use of glucocorticoids was the factor most strongly associated with pD2T-RA status.
Study context
- Population
- Adult RA patients in a single-centre real-life cohort; 104 refractory to ≥ 2 treatments104 refractory to ≥ 2 treatments
- Participants
- 610 patients
- Exposure
- Persistent D2T-RA vs D2T-RA met only episodically
- Outcome
- Prevalence of D2T-RA at each timepoint and persistence (pD2T-RA) over 12 months
- Follow-up
- 12 months
Methodological detailssingle-centre, real-life cohort, bimonthly assessment over previous 12 months, logistic regression
- Single-centre
- Real-life cohort
- Bimonthly assessment over previous 12 months
- Logistic regression
Main finding
As reported in the abstract
Prevalence of D2T-RA among refractory patients
Observational data: associations, not effects.
Further findings
Characteristics associated with persistent D2T-RA (pD2T-RA)
- Associated with male gender, higher HAQ and Charlson Comorbidity Index scores, more failed treatments, and use of non-NSAID analgesics
- Logistic regression: linked to higher SDAI and CRP values, and use of GC or analgesics
- Chronic GC use strongly associated with pD2T-RA
Original publication
Truth unveiled by time and the marbled definition of D2T-RA: retrospective analysis on the persistence of the difficult-to-treat status among refractory RA patients. Arthritis Res Ther. Published 17 September 2024. doi:10.
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