Prevalence and characteristics of adults with difficult-to-treat rheumatoid arthritis in a large patient registry
Authors' conclusion
EULAR's proposed definition of D2T-RA identifies patients with RA who have not achieved treatment targets.
Study context
- Population
- Patients with established rheumatoid arthritis (RA) in the longitudinal BRASS registry (Brigham and Women's Hospital)
- Participants
- 1,581 patients
- Exposure
- D2T-RA vs matched non-D2T-RA
- Outcome
- Prevalence of D2T-RA (EULAR definition)
Methodological detailsregistry-based, matched 2:1 comparison, Poisson regression
- Registry-based
- Matched 2:1 comparison
- Poisson regression
Main finding
As reported in the abstract
Prevalence of D2T-RA, all participants with RA
Prevalence of D2T-RA
14.4 per 100 persons
95% CI 12.8, 16.3
Observational data: associations, not effects.
Further findings
Prevalence of D2T-RA among b/tsDMARD-experienced participants (n=1021)
- Prevalence of D2T-RA
- 22.3 per 100 persons (95% CI 19.9, 25.0)
Characteristics, D2T-RA vs non-D2T-RA
- Several differences in demographics, comorbidities and RA disease activity
D2T-RA prevalence with varying European League Against Rheumatism (EULAR) sub-criteria
- Range of prevalence rates
- 0.6 to 17.5 per 100 persons
Original publication
Prevalence and characteristics of adults with difficult-to-treat rheumatoid arthritis in a large patient registry. Rheumatology (Oxford). Published 5 June 2024. doi:10.
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